Many of our component are COM based. There is a way to use the reg-free COM technology with ASP.Net. By doing so, you don’t need to register the COM in registry and use it in an isolated way.
Here are some more information to start with.
http://www.mazecomputer.com/sxs/help/iis6aspnet2.htm
http://www.bytescout.com/swfscout_example_asp_net_registration_free.html